9-16 11 AM Adeno parvo polyoma

9-16 11 AM Adeno parvo polyoma - Adenovirus, parvovirus,...

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Adenovirus, parvovirus, polyomavirus
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Adenovirus
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Case presentation A 68 year old African American male status post a heart and kidney transplant on immunosuppresive therapy presents with altered mental status, fever, diarrhea, productive cough was found on exam to have decreased breath sounds with bilateral harsh breath sounds, bilateral eye injection and redness. Lab work revealed leukocytosis of 14,000 on initial exam, cultures negative and CT chest revealing patchy consolidation right upper lobe, left lower lobe.
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Adenovirus classification Infect numerous vertebrate species (fish to human) Only vertebrates (so far) 51 human serotypes
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Adenovirus structure, genome From Medical Microbiology, 5 th ed., Murray, Rosenthal & Pfaller, Mosby Inc., 2005, Fig. 53-1. Icosahedral, non enveloped, 90 nM diameter 36 kb (medium sized) linear dsDNA
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E1 E2 E4 E3 Late genes Adenovirus Genome 36 kb (medium sized) linear dsDNA Early genes for host and viral transcription control, viral DNA replication Late genes for virion structure
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Adenovirus replication Replicates and assembles in nucleus via DNA intermediate Uses host transcription apparatus, but modifies it to facilitate virus gene expression Uses oncogenes (E1) in a fashion similar to papillomaviruses Transcription cascade (early and late genes) Encodes virus specific DNA replication apparatus, including viral DNA polymerase
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Adenovirus replication cycle
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Adenovirus pathogenesis Only one third of serotypes cause most clinical disease Widespread Respiratory or fecal-oral tramsmission May establish viremia Replication in respiratory tract, eye, gastrointestinal tract, urinary bladder Persistence for months Responsible for 5% of acute respiratory disease (ARD) in children under 5 ARD in military recruits Conjunctivitis Hemorrhagic cystitis Gastroenteritis and diarrhea Some serotype specificity in pathogenesis
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Adenovirus disease (From Fields Virology, 5th ed, Knipe & Howley, eds, Lippincott Williams & Wilkins, 2007, Table 64.1.)
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From Medical Microbiology, 5 th Adenovirus pathogenesis
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Adenovirus diagnosis Cell culture Viral antigen detection (ELISA, immunofluorescence)
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Adenovirus vaccine Live, wild type enteric coated vaccine for military recruits Asymptomatic infection of gut raises protective immune response for respiratory infection
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Summary: adenovirus Structure Medium sized (36 kb) dsDNA genome, naked capsid Pathogenesis respiratory or fecal oral transmission
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This note was uploaded on 07/02/2011 for the course MMC 6500 taught by Professor Gulig during the Spring '11 term at University of Florida.

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9-16 11 AM Adeno parvo polyoma - Adenovirus, parvovirus,...

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