9-21_11_AM_Enterovirus - Stranded RNA Viruses I Polio The...

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(+) Stranded RNA Viruses I Polio The Common Cold Norwalk Virus
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Totally Paralyzed Poliomyelitis Patients in Mechanical Respirators Last US epidemic before universal immunization (1955).
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Picornaviridae   family 1.  Enterovirus a) Polioviruses  types 1, 2 and 3 b) Coxsackieviruses A1-A24 (no A23), B1-B6 c) Echoviruses 1–34 (no 10 or 28) d) Enteroviruses 68 -71 2.  Rhinovirus a) Rhinoviruses 1 -100+ 3.  Hepatovirus a) Hepatitis A virus 4.  Cardiovirus Caliciviridae   family 1. Norwalk virus 2. Hepatitis E virus
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Biologic properties Heat and detergent stable Acid stability (ability to survive gastric acids following ingestion) a. Enterovirus, Hepatovirus , and Calicivirus are acid-stable (pH >3) b. Rhinovirus is acid-labile (pH <5)
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Virion structure 1. Picornaviridae : non-enveloped icosahedral capsid, 30 nm in diameter, 60 protomers 2. Caliciviridae : nonenveloped icosahedral capsid, 30 – 38 nm, 90 capsomers; named for the 32 characteristic cup-shaped depressions on the virion surface
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Genome structure 1. Linear, plus sense ssRNA, 7 – 8 kb 2. Protein primer at 5’ end, polyadenylated at 3’ end 3. Genome RNA is infectious
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