9-27_1_PM_RNA_Vir_II

9-27_1_PM_RNA_Vir_II - (+) Stranded RNA Viruses II...

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(+) Stranded RNA Viruses II Hemorrhagic Fever and Encephalitis and Rubella   (Togaviridae and Flaviviridae)
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Togaviridae 1. Alphavirus a) Sindbis b) Semliki Forest c) Venezuelan equine encephalitis d) Eastern equine encephalitis e) Western equine encephalitis f) Chikungunya 2. Rubivirus a) Rubella virus (German Measles)
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Flaviviridae 1. Flavivirus includes mostly arthropod-borne viruses a) Dengue b) Yellow fever c) Japanese encephalitis d) West Nile encephalitis e) St. Louis encephalitis f) Russian spring-summer encephalitis g) Powassan encephalitis 2. Hepatitis C a) Hepatitis C virus
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Virion structure 1. Togaviridae : enveloped spherical virion; icosahedral capsid, 45-75 nm in diameter 2. Flaviviridae : enveloped spherical virion; icosahedral capsid, 40 – 50 nm. 3. Heat labile and easily inactivated by detergents
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Negatively Stained Virions of Semliki Forest Virus Togaviridae , genus Alphavirus
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Genome structure 1. Togaviridae : a) linear, plus sense ssRNA, 11 - 12 kb (Alphavirus); 10 kb (Rubivirus) b) 5’ end of genome is capped; polyadenylated at 3’ end c) genome RNA is infectious 2. Flaviviridae : a) linear, plus sense ssRNA, 10.5 - 11 kb (Flavivirus); 9.5 kb (Hepatitis C) b) 5’ end of genome is capped; 3’ end not polyadenylated – a looped structure c) genome RNA is infectious
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Fig. 63-2 Togavirus replication From Murray et. al., Medical Microbiology 5th edition, 2005, Chapter 63, published by Mosby Philadelphia,
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Replication 1. Virion RNA acts as mRNA and is translated into a polyprotein which is co-translationally cleaved (post-translational cleavage for Togaviridae ) to yield non-structural (RNA dependent RNA polymerase) and structural proteins. 2. Cytoplasmic site of replication.
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9-27_1_PM_RNA_Vir_II - (+) Stranded RNA Viruses II...

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