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9-28_11_AM_RNA_viruses_III

9-28_11_AM_RNA_viruses_III - Stranded RNA Viruses III RNA...

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(+) Stranded RNA Viruses III RNA Hepatitis Viruses Hepatitis A, Hepatitis C, Hepatitis E, Hepatitis G
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Distribution of HAV High High/intermediate Intermediate Low Very low
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Hepatitis A (HAV) Picornavirus •Acid stable, non-cytolytic Enterically transmitted (fecal/oral route) Often referred to as “infectious hepatitis” Only a single serotype exists Estimated to be the cause of 40% of acute hepatitis cases General Features
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Hepatitis A (HAV) Enters through the mouth (ingestion) Pathogenesis Multiplies in oropharynx and intestinal epithelial cells Bloodstream Liver
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Hepatitis A (HAV) Virus is abundant in the feces (with some culturable from throat and saliva as well) Incubation time is 4 weeks Abrupt onset of symptoms (15 to 50 days p.I.) and intensify 4 to 6 days before icteric phase Clinical symptoms very similar to HBV (malaise, lethargy) but may be less severe Pathogenesis (con’t)
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Hepatitis A (HAV) Most infections (90%) occur in children who are asymptomatic or anicteric (symptomatic without jaundice) Severity of the disease increases with age (50-75% of adult infections are icteric) By the time “dark urine” appears, most of the virus is gone Virus not cytopathic, liver damage due to cell mediated immune response Pathogenesis (con’t)
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