10-5_10_AM_Emerging_viruses

10-5_10_AM_Emerging_viruses - Emerging Viral Diseases The...

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Emerging Viral Diseases The Concept Factors effecting virus/host evolution Recent examples Hantavirus Ebola virus HIV SARS
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Concept of Emergence Definition: Viral diseases whose incidence (in humans) has increased in the past two decades or threatens to increase in the near future.
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Emergence of new viral diseases 1. Evolution of new organisms. 2. Spread of known viruses to new geographic areas. 3. Infections in persons living in areas undergoing ecological change resulting in exposure to insects or animals harboring the virus.
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Re-emergence of known viral diseases 1. Development of resistance to vaccines or antiviral drugs . 2. Breakdown of public health measures for previously controlled infections
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Re-emergence of known viral diseases 1. Development of resistance to vaccines or antiviral drugs. 2. Breakdown of public health measures for previously controlled infections
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Concept of virus-host equilibrium
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The viral paradox : the need to replicate vs. the need to spread Cellular replication vs. inter- host replication
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Equilibrium human virus 1. Virus has stable relationship with the human host. Virus can maintain infection chain in humans. 2. Virus has no contemporary animal host.
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Equilibrium human virus 1. Virus has stable relationship with the human host. Virus can maintain infection chain in humans. 2. Virus has no contemporary animal host.
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Non-equilibrium human virus 1. Virus has a stable relationship with an animal host.
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Non-equilibrium human virus 1. Virus has a stable relationship with an animal host. 2. Virus can be strikingly lethal since it hasn’t evolved to coexist with humans .
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Non-equilibrium human virus 1. Virus has a stable relationship with an animal host. 2. Virus can be strikingly lethal since it hasn’t
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This note was uploaded on 07/02/2011 for the course MMC 6500 taught by Professor Gulig during the Spring '11 term at University of Florida.

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10-5_10_AM_Emerging_viruses - Emerging Viral Diseases The...

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