{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

bacterial diarrhea 2010 white background

bacterial diarrhea 2010 white background - Clinical...

Info icon This preview shows pages 1–12. Sign up to view the full content.

View Full Document Right Arrow Icon
Clinical Correlation: Enteric Infections Bacterial Diarrhea Chris E. Forsmark, M.D. Division of Gastroenterology,  Hepatology, and Nutrition
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Infectious Diarrhea 3-5 billion episodes yearly Major cause of worldwide morbidity and  mortality 5 million deaths yearly, 80% < 1 year of  age Major cause of work/school  absenteeism Major economic burden, especially in  developing countries Bacteria cause 5.2 million cases of  diarrhea in US yearly (80% foodborne)
Image of page 2
Organisms Bacteria E. Coli, Salmonella, Shigella,  Campylobacter, Vibrio, Yersinia, Clostridium  difficle, S. aureus, B. cereus, C. botulinum Viruses Norovirus, Rotavirus, CMV Parasites Giardia, Amoeba, Ascaris, etc
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
These organisms cause diarrhea  through a wide variety of mechanisms Pathophysiology Osmotic Secretory Exudation Abnormal motility
Image of page 4
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Osmotic Diarrhea Interferes with absorption of water Solutes are ingested (fasting stops  diarrhea) Magnesium sulfate or citrate or magnesium  containing antacids Sorbitol Malabsorption of food Lactase deficiency Celiac sprue Variety of infectious organisms (particularly viruses) Definition: Increased amounts of poorly absorbed, osmotically active solutes in gut lumen
Image of page 6
Secretory Diarrhea Excess secretion of electrolytes and water  across mucosal surface Usually coupled with inhibition of  absorption Clinical features stools very watery stool volume large fasting does not stop diarrhea
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 8
Secretory Diarrhea Bacterial or viral enterotoxins Vibrio cholerae Noncholeraic vibrios Enterotoxigenic  E. coli B. cereus S. aureus Others: Rotavirus, Norovirus Non-infectious causes
Image of page 9

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Exudative Diarrhea Intestinal or colonic mucosa inflamed and  ulcerated Leakage of fluid, blood, pus Impairment of absorption Increased secretion (prostaglandins) The extent and location of bowel involved  determines Severity of diarrhea Systemic signs and symptoms (abdominal  pain, fever, leukocytosis, etc) Tenesmus, urgency
Image of page 10
Exudative Diarrhea Infectious, invasive organisms Shigella, Campylobacter, Yersinia, E. 
Image of page 11

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 12
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern