HIV-students - PATRICK DUFF, M.D. UNIVERSITY OF FLORIDA HIV...

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Unformatted text preview: PATRICK DUFF, M.D. UNIVERSITY OF FLORIDA HIV INFECTION HIV INFECTION LEARNING OBJECTIVES Describe the pathophysiology of HIV infection. Describe the principal mechanisms of transmission of HIV infection. Describe the diagnostic algorithm for HIV infection. Describe measures for prevention and treatment of HIV infection. HIV INFECTION KEY QUESTIONS Most common mechanisms of transmission Diagnostic algorithm Indications for treatment Preventive measures HIV INFECTION VIRAL STRUCTURE HIV INFECTION VIROLOGY RNA retrovirus Two major strains HIV-1 HIV-2 HIV INFECTION VIRAL STRUCTURE HIV INFECTION KEY VIRAL ENZYMES Reverse transcriptase Integrase Protease HIV INFECTION PATHOPHYSIOLOGY HIV INFECTION PATHOPHYSIOLOGY HIV INFECTION GENETIC DIVERSITY  Replication cycle - 2.5 days A 1 billion virions each day A 10 trillion virions during course of illness A Replication errors changes in genome drug resistance STAGES OF HIV INFECTION Acute retroviral illness Latent phase Symptomatic phase AIDS fatal outcome MOST COMMON SERIOUS OPPORTUNISTIC DISEASES  Pneumocystis jiroveci(carinii) pneumonia A Kaposis sarcoma A MAC OTHER IMPORTANT OPPORTUNISTIC DISEASES TB Toxoplasmosis CMV infection Candidiasis Non-Hodgkins lymphoma PRINCIPAL MECHANISMS OF TRANSMISSION Sexual contact IVDU Perinatal EPIDEMIOLOGY OF HIV INFECTION 5 10 15 20 25 30 35 40 World U.S....
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HIV-students - PATRICK DUFF, M.D. UNIVERSITY OF FLORIDA HIV...

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