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Unformatted text preview: Pedigree Analysis Pages 66-71 Pedigree Analysis- Deduction single gene inheritance of human phenotypes by a study of the progeny of mating within a family, often stretching back several generations. • A member of a family who first comes to attention of a genecist is called the propositus. The phenotype of this person is exceptional in some way. This person's phenotype is traced back. To see single gene interaction, the patterns in the pedigree have to be interpreted according to Mendel's Law of Equal Segregation, but in humans there is a small progeny size and the ratios are not seen. • Approach to pedigree analysis also depends on whether one of the contrasting phenotypes is a rare disorder or both phenotypes of a pair are common morphs of a polymorphism. • There are two phenotypes present: the presence of the disorder and the absence of the disorder Autosomal Recessive Disorder • The affected phenotype of an autosomal recessive disorder is inherited as a recessive allele and...
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This note was uploaded on 06/27/2011 for the course BIOL 202 taught by Professor Kieber-hogan during the Spring '08 term at UNC.
- Spring '08