35a_Models_and_Reverse_Genetics

35a_Models_and_Reverse_Genetics - Model Organisms and...

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Model Organisms and  Reverse Genetics J. Lieb Wild-type Bmp7 -/- Mouse Embryos
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Nature supports an incredible diversity of body plans
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Yet all of these organisms share  conserved molecular processes  (Bio 202) and developmental  mechanisms (Bio 205) that are  evidence of their evolution from a  common ancestor A major challenge in biology is to understand both this unity and this  diversity
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"Model" Organisms in Biology What allows us to use them? 1.  All organisms share similar cellular machinery 2.  All animals use this machinery in similar ways to direct embryonic  development   Why use them? Perform controlled experiments on a large number of samples What does one look for when choosing a model? Fast, cheap, easy to observe and manipulate, and has the feature you  want to study
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Why Models Matter The Example of Mutation of the Kit gene in humans and mice “Piebaldism”: Affected individuals may be anemic, sterile, deaf, and lack pigment in certain skin cells.
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