Lecture_13_Linkage_2011 (1)

Lecture_13_Linkage_2011 (1) - Linkage Recombination Feb...

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Linkage & Recombination Feb. 11 th , 2011
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Announcements 3 rd problem set online, due Feb 18 th at 4:00 pm
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Review EPISTASIS describes gene-gene interactions in which an allele at one locus can “override” an allele at another. Epistatic alleles can be RECESSIVE or DOMINANT . Another gene-gene interaction is SUPPRESSION which describes the ability of a mutant allele at one locus to compensate for the defect in a mutant allele at another locus. Gene-gene interactions can create lethal phenotypes called SYNTHETIC LETHALS . PENETRANCE and EXPRESSIVITY describe the proportion of a population expressing the phenotype of a given genotype, and the degree to which they express it respectively.
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Recombination INPUT MEIOSIS OUTPUT Recombination has occurred if the genotype of a gamete is different than the input haploid genotypes. o INDEPENDENT ASSORTMENT o CROSSING OVER
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Unlinked Genes
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Independent Assortment Review F1: A/a;B/b Possible gametes: AB Ab aB ab Parents: A/A;B/B X a/a;b/b note: parent 1 has only big alleles and parent 2 has only little alleles
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  • Spring '08
  • Kieber-Hogan
  • Chromosomal crossover, ab ab ab, nonrecombinant chr rossover, Assortment Review, chromatids chiasmata

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