8.part.bioaccum.10 - Partitioning and Bioaccumulation...

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Partitioning and Bioaccumulation Organic Phase Partitioning Risk, Exposure and Dose Bioaccumulation Absorption, Disposition, Depuration Kinetic Modeling Summary and Conclusions
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I. Organic Phase Partitioning Octanol-water coefficient estimates the partitioning of a chemical between aqueous and organic phases. Octanol serves as a model for organics (soil carbon or adipose tissues). Partitioning (soils, biota): K ow = C octanol /C water (typically recorded
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K ow is Inversely Proportional to Solubility
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K ow Estimates “Organic” Solubility Neutral organics are much more soluble in organic phases. Neutral organics are generally more fat soluble with increasing molecular mass. In the environment large neutral organics tend to be associated with the organic carbon fraction of soils and the adipose tissues of organisms.
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II. Risk, Exposure and Dose Risk is the probability that a chemical exposure will cause a toxic effect.
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