24.trans.infl.tox.10

24.trans.infl.tox.10 - Special Topic: How Transformations...

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Unformatted text preview: Special Topic: How Transformations Influence Toxicity Introduction Some Processes in Vascular Plants Some Processes in Vertebrates Summary and Conclusions I. Introduction Reactions often directly detoxify a chemical. Reactions almost always increase water solubility of a chemical. However, chemicals may be instead activated. Differences in toxicity are often traced to differences in biodegradation. II. Some Processes in Vascular Plants Monuron, a substituted urea class herbicide, is used in cotton fields and on other crops. Cotton is selectively resistant via P450-catalyzed N-demethylation (oxidation). Some Processes in Vascular Plants Propanil, an acetanilide herbicide, is commonly used for weed control on many crops, including rice, potatoes and wheat. Most crops are selectively resistant via amidase-catalyzed hydrolysis. The weeds are often not! Some Processes in Vascular Plants Atrazine, a triazine herbicide, is commonly used in for weed control in corn fields. Corn is selectively resistant via GST-catalyzed glutathione conjugation (Cl is the leaving group)....
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This note was uploaded on 06/29/2011 for the course GENETICS 101 taught by Professor Debrakimbrell during the Summer '09 term at UC Davis.

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24.trans.infl.tox.10 - Special Topic: How Transformations...

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