Ch 27 b - CHAPTER 27 Population Genetics Dr. Sanghamitra...

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CHAPTER 27 Population Genetics Dr. Sanghamitra Mohanty
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27.1 Allele Frequencies in Population Gene Pools Vary in Space and Time A population is a group of individuals with a common set of genes that lives in the same geographic area and actively or potentially interbreed. A population’s gene pool is all of the alleles present in that population. Due to population dynamics, the gene pool can change over time.
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27.2 The Hardy-Weinberg Law Describes the Relationship between Allele Frequencies and Genotype Frequencies in an Ideal Population
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The Hardy-Weinberg model assumes that: there is no selection no new alleles arise from mutation there is no migration into or out of the population the population is infinitely large random mating occurs
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The  Hardy-Weinberg law  makes two predictions: the frequency of the alleles in the gene pool does not  change over time after one generation of random mating, the genotype  frequencies for two alleles can be calculated as  p 2 + 2 pq  +  q 2 = 1 p  equals the frequency of allele  A q  is the frequency of allele  a  
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For a For a two-allele system two-allele system , the expected , the expected genotypic frequencies for a population in genotypic frequencies for a population in Hardy-Weinberg equilibrium can be calculated Hardy-Weinberg equilibrium can be calculated based on allele frequencies in gametes and based on allele frequencies in gametes and random mating ( random mating ( Figure 27.1 Figure 27.1 and and Figure Figure 27.2 27.2 ). ).
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Applied to Human Populations Analysis of susceptibility to HIV-1 infection based on the genotype for the CCR5 HIV-1 receptor gene ( Table 27.1 and Table 27.2 ). This can be assessed by a PCR and restriction-
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This note was uploaded on 07/04/2011 for the course BIO 325 taught by Professor Saxena during the Fall '08 term at University of Texas at Austin.

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Ch 27 b - CHAPTER 27 Population Genetics Dr. Sanghamitra...

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