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Unformatted text preview: temporary reduction in number. It affects population by changing allelic frequencies, reducing genetic variation within population and increasing genetic variants among populations. Problems: 1) If we assume p represent the frequency of wildtype allele and q represents the mutant (lossoffunction) allele; and we assume that the population is in HardyWeinberg equilibrium, then the frequencies of the genotypes are given by p2 for homozygous normal, q2 for individuals with TaySachs and 2pq for heterozygous carriers. q = q2 = 1/ 3600 = 1/60 = 0.017 Since, p + q = 1, p = 1 0.017 = 0.983 Therefore, the frequency of carriers is, 2pq = 2 (0.017) (0.983) = 0.033 = 1 in 30. 2) Frequency of A = p = 0.2 + 0.6/2 = 0.2 + 0.3 = 0.5 q = 1p = 0.5 In the second generation, Frequency of AA = (0.5)2 = 0.25 0r 25% Frequency of Aa = 2pq = 2 (0.5) (0.5) = 0.5 or 50% Frequency of aa = q2 = (0.5)2 = 0.25 = 25%...
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 Fall '08
 SAXENA
 Genetics, Mutation

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