Chapter 12 - CHAPTER 12 DNA Organization in Chromosomes Dr....

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Unformatted text preview: CHAPTER 12 DNA Organization in Chromosomes Dr. Sanghamitra Mohanty Chapter contents: Supercoiling of DNA Variation in the organizations of the DNA Organization of DNA into Chromatin in eukaryotes Chromosome Banding Repetitive DNA sequence 12.1 Viral and Bacterial Chromosomes Are Relatively Simple DNA Molecules Bacterial and viral chromosomes are usually: a single nucleic acid molecule largely devoid of associated proteins much smaller than eukaryotic chromosomes Chromosomes of viruses consist of single- or double-stranded DNA or RNA. Bacterial chromosomes are double-stranded DNA and are compacted into a nucleoid . DNA in bacteria may be associated with HU and HI DNA-binding proteins . 12.2 Supercoiling Facilitates Compaction of the DNA of Viral and Bacterial Chromosomes Supercoiling compacts DNA ( Figure 12.4 ). Most closed circular DNA molecules in bacteria are slightly underwound and supercoiled. Topoisomerases cut one or both DNA strands and wind or unwind the helix before resealing the ends. Polytene chromosomes and...
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This note was uploaded on 07/04/2011 for the course BIO 325 taught by Professor Saxena during the Fall '08 term at University of Texas at Austin.

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Chapter 12 - CHAPTER 12 DNA Organization in Chromosomes Dr....

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