November 3 notes - Calcium and Vitamin D MD's View of Rx...

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Calcium and Vitamin D MD’s View of Rx for Bone Health MD’s View of Rx for Bone Health 175
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Modifiable risk factors of sub-optimal bone health Diet Sun Physical Activity level and type (weight-bearing) of activity Disease/drug therapy Gender Body size phisms Metabolism Calcium •nutrients altering excretion •nutrients altering absorption Vitamin D for calcium homeostasis and bone turnover Genetics Bone Health 176
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Vitamin D Definition not a true vitamin mechanism of action is that of a steroid hormone not required in diet by normal humans normally de novo synthesis in human tissues 177
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Sources of Vitamin D: Diet and Sun (Calvo J Nutr 2005) Major sources fortified dairy products (mandated by law) margarines now in orange juice! 178
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Nomenclature Calciol (cholecalciferol, vitamin D 3 ) Parent compound No biological function Calcidiol (25-hydroxycholecalciferol, 25-OH D 3 ) Major plasma metabolite Index of status Calcitriol (1,25-dihydroxycholecalciferol, 1,25-(OH) 2 D 3 ) Active hormone Vitamin D-Binding Protein (DBP, transcalciferin) In plasma 179
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180
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Metabolism of Dietary Vitamin D
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This note was uploaded on 07/06/2011 for the course BIOCHEM BIOCHEM 3N taught by Professor Macdonald during the Spring '11 term at McMaster University.

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November 3 notes - Calcium and Vitamin D MD's View of Rx...

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