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November 11 notes - Summary of last lecture Vitamin D...

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Summary of last lecture Vitamin D mechanism: Genomic vs. non-genomic Calcium and P homeostasis is regulated by three hormones PTH 1,25-(OH) 2 D 3 Calcitonin Intestine BBM: transcaltachia, gated Ca 2+ channels, alkaline phosphatase, Na + -dependent P transporters, Cytosol: calbindin, Basolateral membrane: Ca 2+ -Mg 2+ ATPase, Na + -Ca 2+ ATPase Kidney synthesis of renal calbindin stimulates reabsorption of Ca 2+ Bone Osteoblasts: 1,25-(OH) 2 D 3 induces differentiation of osteoblasts Osteoclasts: inhibited by calcitonin
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Dietary calcium and healthy weight Health Claim Allowed for Dairy Food Labels/ advertising (2004) “A healthy diet with adequate calcium and vitamin D, and regular physical activity, help to achieve strong bones and may reduce the risk of osteoporosis” Food must contain at least 200 mg calcium and 1.25 µg (50IU) vitamin D per serving . 229
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Calcium: a macromineral 5 th most abundant element in biosphere after Fe, Al, Si, O
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