October 4 notes - Summary of last lecture Endogenous vs....

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Summary of last lecture Endogenous vs. exogenous lipids Processing of lipoproteins by the body Importance and role of CM, CR, VLDL, LDL, HDL, albumin Role of apoproteins ApoB-100 ApoE ApoC-2 ApoA-1 Receptor-mediated uptake of CR and LDL Lipid metabolism in liver and adipose tissue post- prandial
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1. Biosynthesis (Fig 6.21) Negative feedback regulation of endogenous cholesterol synthesis is mediated via total cell [cholesterol]: suppresses transcription of gene for rate-limiting enzyme in cholesterol synthesis (HMGCoA reductase in liver) Block de novo synthesis of cholesterol suppress transcription of gene for LDL receptor Block additional uptake of cholesterol from plasma LDL 67
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Fig 6.34 68
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2. Diet: Effects of cholesterol, fat and fibre on liver cholesterol pool i) Cholesterol total cholesterol in diet ii) Fat amount of total fat concentration of acetylCoA precursor available for cholesterol synthesis saturated fat LDL-cholesterol by suppressing LDL receptor activity and excretion of bile acids and control of HMGCoA reductase trans fatty acids LDL similar to saturated fats mono- and polyunsaturated fats reduce LDL-cholesterol and raise HDL-cholesterol 69
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iii) Fibre reduces cholesterol absorption by increasing fecal excretion: soluble fibre : binds cholesterol and bile salts blocking absorption and re-absorption
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This note was uploaded on 07/06/2011 for the course BIOCHEM BIOCHEM 3N taught by Professor Macdonald during the Spring '11 term at McMaster University.

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October 4 notes - Summary of last lecture Endogenous vs....

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