Unformatted text preview: Name: “We x Student Number: 4. Endogenous foreign antigen is processed by the pr 61?“. so me V to be loaded into V - V
ch, class 1 molecuies for presentation to 069% NNVE CD’S ‘T-alls 5. List the 3 key factors that are important in the differentiation of W 1 cells.
IL.- \L/ dehdw'i'lc. 'Cgl’okme s’rwnulahon b% w relentee fram- Mil cells ground-e, 5 TE“! ‘M High chFuwl-g tn—l-u/cc’ﬂoh Uni-Kn. m‘r‘Q, V
'ngln 59M“? of WHCWH’FIg'ew V 6. Diversity of the B cell and T cell repertoire is generated by recombination of a limited number of gene sequences (somatic diversiﬁcation). V, D and J gene sequences are joined in a process that requires V03 ”Comet “use ’/ . ER 6 '3: 8/ and
g 3 A 6 ~ 1 ‘ are critical protems 1n thls process. R 9.9-1 3 and RA 9-1 ‘3— knock-out mice have no '1' cells and l5 CaliS . . . (1/
7. The thymus 13 011th3.1 for the development of "T - C6“ S
/‘ Following all?) 'T-ccll receptor rearrangement, the cells undergo positive and negative selection.
Positive selection ensures that only cells speciﬁc for peptides bound to self MHC mature in the . 1/
thymus. This process is also referred to as P'MC rasd'wdrtor‘ and critically requires
theme mini epttkdwd cells. T cells that recognize self peptide:self MI-IC complex too well are ' I
eliminated through negative selection, also referred to as get? 4‘0 lake-nee. /Z~ . bone ov row derived 9 C \ S / cells are critically involved in this process. lit 5 f 11102 'T‘pet £7 NnvF-mher 0th 7.004“ Page 2 of5 ...
View Full Document
- Spring '11