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11AI-renal_topics - active transport primary secondary...

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1 Some concepts and anatomical structures discussed in the Renal lectures (W'11) overall renal function water balance renal failure distribution of body fluids two types of renal systems (secretion-only vs filtration/reabsorption/secretion) anatomy ureter, bladder, sphincters, urethra renal artery, renal vein, arterioles nephron, juxtaglomerular apparatus, loop of Henle, collecting tubule, renal pelvis glomerulus, peritubular capillaries sympathetic & parasympathetic circuits for controlling micturition filtration direction of blood flow direction of filtrate flow fenestrae, basement membrane, filtration slits, podocytes forces involved in glomerular filtration net glomerular filtration pressure filtration - what moves, what doesn't, and why glomerular filtration rate (GFR) change in net filtration force after filtration reabsorption, secretion, excretion, return to venous system luminal & basolateral membranes of renal tubule epithelial cells
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Unformatted text preview: active transport - primary, secondary reabsorption of Na, glucose, H 2 O, Cl, K, urea, bicarbonate K secretion H + "secretion" Na-HCO 3 co-transport regulation of renal function myogenic response juxtaglomerular apparatus, macula densa, granular cells tubulo-glomerular feedback (TGF) baroreceptor reflex change in width of filtration slits response to decrease in NaCl, extracellular fluid volume, blood pressure renin, angiotensinogen, angiotensin II, aldosterone atrial natriuretic peptide regulation of K secretion & Na reabsorption response to increased osmolarity (loss of hypotonic fluid) 2 water permeability aquaporins water permeability selectivity filter proton wires NKCC2 transporter counter-current multiplication AQP1, AQP2, AQP3 anti-diuretic hormone water movement in presence of anti-diuretic hormone movement of water at different locations along tubule urea how to make a more dilute urine diabetes insipidus how to make a more concentrated urine...
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  • Winter '08
  • Fuller,Charles/Goldberg,Jack
  • renal tubule, Renal artery, glomerular filtration, filtration slits, overall renal function

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