CHAP 17 - Innate immunity Non-specific defenses against any...

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Innate immunity - Non-specific defenses against any pathogen. (genetically determined) · Adaptive immunity : Specific lymphocyte response (B-cells and T-cells) to an antigen. o Acquired immunity -Developed during an individual's lifetime *2 types: § Humoral (antibody-mediated) immunity - Involves Ab production by B cells; mostly against bacteria, toxins, and viruses Lymphocytes in bone marrow become Bcells § Cell-mediated immunity- Involves T cells; response is against intracellular pathogens and transplanted tissue T cell receptors recognize antigens · I mmunity -the body’s defense against particular pathogentic microorganisms · Nonspecific resistance -develops during the beginning of life w/out contact w/ any parasite or its products & its not-specific for any particular parasiste TYPES OF ACQUIRED IMMUNITY v NATURALLY ACUIRED ú Active: antigens enter the body naturally, body induces antibodies and specialized lymphocytes; involve when someone is exposed to antigens, gets ill, recovers and then has lifelong immunity to that disease (immunity may not be lifelong) ú Passive: antibodies pass from mother to fetus via placenta or to infact via breast milk; result is newborn temporarily immune to same antigens mom is (Transplacental or via colostrum ) v ARTIFICIALLY ACQUIRED ú Active: antigens are introduced into body (vaccines and immunization) and body produces antibodies and specialized lymphocytes ú Passive: preformed antibodied in immune serum are injected; come from animal or person who is already immune to the disease · ANTIGEN o proteins or large polysaccharide molecules o often components of invading microbes such as capsules, cell walls, fimbraie, and bacteria toxins o nonmicrobial antigens: pollen, egg white, blood cell surface molecules o EPITOPES or ANTIGENIC DETERMINANTS: antibodies recognize and interact with specific regions on antigen · HAPTEN o Low molecular weight compounds that are not antigenic unless combined with a larger carried molecule o Once antibody against hapten formed, the antibody reacts with hapten away from carrier molecule
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This note was uploaded on 07/12/2011 for the course NURSING 000 taught by Professor Clark during the Spring '11 term at Alabama.

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CHAP 17 - Innate immunity Non-specific defenses against any...

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