CHAP 17 - Innate immunity- Non-specific defenses against...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Innate immunity - Non-specific defenses against any pathogen. (genetically determined) · Adaptive immunity : Specific lymphocyte response (B-cells and T-cells) to an antigen. o Acquired immunity -Developed during an individual's lifetime *2 types: § Humoral (antibody-mediated) immunity - Involves Ab production by B cells; mostly against bacteria, toxins, and viruses Lymphocytes in bone marrow become Bcells § Cell-mediated immunity- Involves T cells; response is against intracellular pathogens and transplanted tissue T cell receptors recognize antigens · I mmunity -the body’s defense against particular pathogentic microorganisms · Nonspecific resistance -develops during the beginning of life w/out contact w/ any parasite or its products & its not-specific for any particular parasiste TYPES OF ACQUIRED IMMUNITY v NATURALLY ACUIRED ú Active: antigens enter the body naturally, body induces antibodies and specialized lymphocytes; involve when someone is exposed to antigens, gets ill, recovers and then has lifelong immunity to that disease (immunity may not be lifelong) ú Passive: antibodies pass from mother to fetus via placenta or to infact via breast milk; result is newborn temporarily immune to same antigens mom is (Transplacental or via colostrum ) v ARTIFICIALLY ACQUIRED ú Active: antigens are introduced into body (vaccines and immunization) and body produces antibodies and specialized lymphocytes ú Passive: preformed antibodied in immune serum are injected; come from animal or person who is already immune to the disease · ANTIGEN o proteins or large polysaccharide molecules o often components of invading microbes such as capsules, cell walls, fimbraie, and bacteria toxins o nonmicrobial antigens: pollen, egg white, blood cell surface molecules o EPITOPES or ANTIGENIC DETERMINANTS: antibodies recognize and interact with specific regions on antigen · HAPTEN o Low molecular weight compounds that are not antigenic unless combined with a larger carried molecule o Once antibody against hapten formed, the antibody reacts with hapten away from carrier molecule
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 3

CHAP 17 - Innate immunity- Non-specific defenses against...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online