NUR 305 test 1 C

NUR 305 test 1 C - 1 Notes for Test 1 C Immunity o Innate...

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Unformatted text preview: 1 Notes for Test 1 C Immunity o Innate Immunity First line of defense o In flammation Second line of defense o Acquired (Adaptive) Immunity Third line of defense Chapter 4 I nnate Immunity o First line of defense o Physical and mechanical barriers Skin, linings of GI, GU, and respiratory tract o Biochemical barriers Saliva, tears, sweat, mucous Antimicrobial peptides Proteins that can attack certain viruses, bacteria, and fungi Normal bacteria flora If you take antibiotics, you kill your normal flora o You can get yeast infections when you destroy normal flora CMs: Thrush and vaginal yeast infections (women) Big gun antibiotic = yeast infection for women I nflammation o Second line of defense o Vascular response Blood vessels dilate (increases blood flow) Increased blood vessel permeability, resulting in leaking of plasma which forms exudates (edema and swelling) Shift of fluid from 2 nd space to 3 rd space WBCs (leukocytes) adhere to inner walls of vessels and migrate to injury site o Look at bottom of CBC to see the WBC differential count, which is the number of eosinophils, basophils, leukocytes, etc. (tells you what kind of infection and if body is responding correctly) 2 o Mast cells Activator of inflammatory response Cellular bags of granules located in the connective tissue close to blood vessels Found in skin, lining of GI, lining of respiratory tract. Start the inflammatory process by releasing biochemical mediators in two ways: (1) Degranulation (bags rupture and granules go to injury site) (2) Synthesis of mediators (if granules arent enough, we make more chemicals) H istamine Vasoactive amine that causes temporary, rapid constriction of the blood vessels and dilation of the venules. Retraction of endothelial cells lining the capillaries Receptors o H1 receptor (pro-inflammatory) Involves respiratory tract o H2 receptor (anti-inflammatory) Involves GI tract Give antihistamine to prevent ulcers, which are caused by stress and increased acid production Antihistamine drugs prevent histamine from binding and decrease inflammation o Taken for allergies o Body has started inflammation response to stimulation, but that causes problems as well, so you take antihistamine o You have to take drugs that are specific to the correct histamine receptor Mast cell degranulation Chemotactic factors o Factors that are specific to different cells that attract those cells to the site of injury o Neutrophil chemotactic factor 3 Attracts neutrophils to the injury site, do most of the work in the early stages. o Eosinophil chemotactic factor Attracts eosinophils to the injury site Mast cell synthesis of mediators Leukotrienes o Similar to histamine but slower acting and longer lasting (important in later stages of inflammation) Prostaglandins o Increase vascular permeability o Induce pain Platelet activating factor...
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This note was uploaded on 07/12/2011 for the course NURSING 000 taught by Professor Clark during the Spring '11 term at Alabama.

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NUR 305 test 1 C - 1 Notes for Test 1 C Immunity o Innate...

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