Lec_3_coscey - Lec 3- Signaling Biochemistry Consequences...

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Lec 3- Signaling Biochemistry Consequences of TCR signaling? -clonal expansion (secrete IL2; cell division) - effector functions (secrete cytokines-Th; killer func activated-CTLs) Big Picture: TCR signal=> …. => Gene expression alterations General Principle: Initial step in signal transduction is ligand induced dimerization (clustering) Phosphorylation=dynamic, reversible way of modulation protein function Kinase=enzyme that attaché phosphate groups to specific AA of proteins (Y, S, T) How TCR transducer signals with small tail?? help of CD3 complex (its ITAMs) ITAMs: “immune tyrosine activation motif” -essential for TCR signaling -(YXXI/L-XXXXXX-YXXI/L) 2 SH2 domains -tyrosine phosphorylated = activation SH2 domains: bind to specific phosphotyrosinated protein domains PTK: Protein Tyrosine Kinases (initial TCR signaling) =>Src family – fyn, lck (SH3; SH2; Kinase with inhib + stim regulatory Y) =>Syk family – zap 70 (SH2; Sh2; Kinase with 1 reg Y) Regulating PTK activity
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This note was uploaded on 04/04/2008 for the course MCB 150 taught by Professor Coscey during the Spring '08 term at University of California, Berkeley.

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