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Unformatted text preview: TCR rearrangement very similar to Ig rearrangement preT – alpha: beta chain rearrangement successful stim alpha chain rearrangement; if inproper beta chian new TCR beta (RAG expression) TCR beta req for DN DP pTCR independent of ligand; doesn’t require extracellular domains; beta selection leads to proliferation (DN2 & DN3) DN: cd44+cd25- cd44+cd25+ preTCR prolif (beta rearrangement) DP: CD8+CD4+ TCR (alpha rearrangement) TCRalpha rearrangment removes the delta locus Gamma-delta T cells: in fetus; DETC: wound healing; don’t need MHC to bind to Ag...
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This note was uploaded on 04/04/2008 for the course MCB 150 taught by Professor Coscey during the Spring '08 term at Berkeley.
- Spring '08