Extended dumps deficiency of uridine monophosphate

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: in gestation and are reabsorbed (during the first two months) • Calving intervals are extended DUMPS – Deficiency of Uridine Monophosphate Synthase • Sires implicated: Skokie Sensation Ned • Incidence- Less than 2% of Holsteins were heterozygous at peak • Testing procedures: blood test for the activity of the enzyme uridine monophosphate synthase, heterozygotes have half the normal levels Complex Vertebral Malformation • CVM – a new recessive genetic disease of Holstein cattle • Homozygotes for CVM are usually aborted prior to day 260 of gestation • Those born in late gestation are always stillborn, usually prior to the due date • CVM calves have malformed legs with flexed and rigid pasterns and an abnormal curvature to the spine Full-term Holstein calf with CVM Complex Vertebral Malformation • CVM appears to have been spread within the Holstein breed by Bell, the same bull responsible for BLAD!! • Sons of Bell known to be carriers via DNA testing are: – Elton – Southwind – Belltone What is the extent of the CVM problem? • Bell – over 79,000 daughters and 1281 proven sons • Elton – over 26,000 daughters and 345 proven sons • Southwind – over 49,000 daughters and 309 proven sons • Belltone – over 45,000 daughters and 45 proven sons • Fatal – over 52,000 daughters worldwide and 104 proven sons, also a BLAD carrier What should be done about CVM? • Sires are being tested for CVM and their status will be added to their names. – Bulls testing negative (homozygous normal) will be labeled TV – Bulls testing positive (heterozygotes) will be labeled CV • Daughters and granddaughters of CV bulls should not be bred to CV sires How will bull studs deal with CVM? • Reduce or eliminate usage of CVM carrier bulls as sires of young sires • Superovulate only CVM negative cows as bull mothers • Test all young sires prior to beginning their progeny testing program, cull carriers of CVM • Over time, CVM will cease to be a problem Genetic Defects of Brown Swiss • Weaver Syndrome – Progressive degenerative...
View Full Document

This note was uploaded on 07/16/2011 for the course ANS 3384 taught by Professor Olson during the Spring '09 term at University of Florida.

Ask a homework question - tutors are online