Lecture5-6

1m nacl 1 a molar concentration of a depletion force

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Unformatted text preview: M NaCl: 1/ = [A] … molar concentration of A “Depletion Force” Evans & Needham 1988 1988 Energy RG k BT Area dextran radius of bulk density gyration density gyration Follow-up Things worth remembering (among others) “Effectors” of biomolecular interactions: • • • • • • • electrostatic van der Waals covalent bond hydrogen bond hydrophobic interaction depletion force screening of charges What are depletion forces? Essence of Debye-Hückel theory, including simplified solution of Poisson-Boltzmann equation; Debye length BIM 162 UC Davis, BME Quantitative Concepts in Biomolecular Engineering Moving biomolecules: Random walks and random coils Brownian motion: Diffusion ? Random walk D … diffusion coefficient (units: length2/time) ? … friction coefficient (units: force/velocity) Diffusion:...
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