Lecture5-6

Lecture5 6

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Unformatted text preview: UC Davis, BME BIM 162 Quantitative Concepts in Biomolecular Engineering Lectures 05/06 Interactions between biomolecules and their aggregates / Moving biomolecules Follow-up Things worth remembering (among others) Difference between probability density and probability Calculation of average (or “expectation value”) What causes some interactions to be always attractive? Interactions between (bio)molecules “Hydrophobic interactions” “water-fearing” (?) Example: Toughness of membranes is (mainly) due to hydrophobic interactions DPPC Color scheme: PO4 = green, N(CH3)3 = violet, water = blue, bl terminal CH3 = yellow, O = red, glycol glycol C = brown, brown, chain C = gray. http://helix.nih.gov/research/rvenable.html Example: Toughness of membranes is (mainly) due to hydrophobic interactions Automated Automated pipette aspiration to measure the cohesive strength th of of membranes Automated pipette aspiration to measure the cohesive strength th of of membranes Automated pipette aspiration to to measure the cohesive strength of membranes Lysis Dynamic Tension Spectroscopy Evans, Heinrich, Ludwig & Rawicz (2003) Screening of interactions between charged (bio)molecules (bio)molecules Dilemma: For any interaction between pairs...
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