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Exam 2 Fall 2009 - Answers

Exam 2 Fall 2009 - Answers - Principles of Drug Action(BIO...

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Principles of Drug Action (BIO 365D) Test #2 Name: _____________________________ October 26, 2009 Each of the 12 multiple choice questions is worth 0.75 marks out of 30 . 1. Selectivity of drug distribution can be achieved in many ways. For example propantheline and atropine are both good muscarinic blockers but the former does not cross the blood-brain barrier because it has a quaternary nitrogen. This is an example of selectivity due to A. Differential topical application B. Distribution by selective carriers C. Differential blood flow D. Differential ionization E. Differential concentration by excretion. 2. Which of the following statements is FALSE ? A. Cooperativity of acetylcholine binding at the nicotinic acetylcholine receptor means that the binding of one acetylcholine molecule affects the affinity of the second acetylcholine molecule to bind. B. Ionotropic receptors can adopt one of three major conformational states: closed, open and desensitized. C. Cys-loop receptors, such as the ionotropic GABA and nicotinic receptors, are composed of five subunits. D. Glutamate receptor subunits have a re-entrant loop in transmembrane domain 2. E. Ionotropic receptors activate more slowly than metabotropic receptors. 3. Diacylglycerol (DAG) does which of the following 4. If in a population 16% of the people exhibit a recessive disorder, what is the prevalence of the recessive gene in the population and what proportion of people are carriers but not afflicted? 5. You are a physician treating an twelve year-old child who weighs 40 kg. If the adult dose of the drug you wish to prescribe is 10 mg/day how much drug should you give this child?
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