2010 all exams - Principles of Drug Action (BIO 365) Test...

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Principles of Drug Action (BIO 365) Test #1 Name:_____________________________ February 17, 2010 Each of the 12 multiple choice questions is worth 1 mark out of 30 . 1. The chemical modification of the mold-derived antibiotic penicillin to create the new antibiotic oxacillin means that oxacillin is an example of a A. Pure compound. B. Galenical. C. Semi-synthetic compound. D. Synthetic compound. E. None of the above. 2. Which one of the following statements is TRUE ? A. Percutaneous drug administrations are always topical. B. Drugs administered sublingually tend to be absorbed slowly. C. Drugs administered via suppository are subject to the first-pass effect. D. An intra-arterial injection can be a form of topical drug administration. E. Diabetics typically self-administer insulin intraperitoneally. 3. The blood:brain barrier is made of A. occluded capillaries B. fenestrated capillaries C. capillaries with maculae D. occluded capillaries and fenestrated capillaries E. capillaries with maculae and fenestrated capillaries 4. Assume that n-butane (CH3CH2CH2CH3) has a membrane/buffer partition coefficient of 10. If adding a hydroxyl group to an aliphatic molecule like butane changes its membrane/buffer partition coefficient by a factor of 0.1, what will be the membrane partition coefficient of n-butanol (CH3CH2CH2CH2OH)? A. 11 B. 9 C. 9.9 D. 10.1 E. 1 5. You have determined the following volumes of distribution of different agents in your patient, as follows: alcohol has a Vd of 50 L; mannitol has a Vd of 20 L and Evans Blue has a Vd of 5 L. How much INTRA cellular water does he have? A. 5 L B. 15 L C. 20 L D. 30 L E. 45 L 6. Most blood flow TO the liver comes from the A. hepatic artery B. portal vein C. hepatic vein D. central vein E. aorta
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7. If the GFR is 125 ml/min but a drug’s clearance is 80 ml/min this means A. the drug must be reabsorbed as well as filtered. B. the drug must be secreted as well as filtered. C. the drug must be filtered especially thoroughly. D. the drug must be increasing blood perfusion of the kidney E. the patient must be bleeding internally in order to explain this rapid clearance. . 8. Which portion of the nephron is most impermeable to water ? A. Glomerulus B. Proximal tubule C. Descending Loop of Henle D. Ascending Loop of Henle E. Distal tubule (in the presence of ADH) 9. In the blood the most important molecule for nonspecific drug binding is? A. haemoglobin B. lipoproteins C. globulins D. albumin. E. bilirubin. 10. Which one of the following statements is FALSE ? A. Hydrolysis and oxidation reactions are examples of phase II reactions. B. Drugs may undergo phase II reactions without the need to first undergo phase I reactions. C.
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2010 all exams - Principles of Drug Action (BIO 365) Test...

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