2007 test2 - Principles of Drug Action (BIO 365D) Test #2...

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Principles of Drug Action (BIO 365D) Test #2 Name:_____________________________ March 28, 2007 Each of the 12 multiple choice questions is worth 0.75 marks out of 30 . 1. Selectivity of drug distribution can be achieved in many ways. For example propantheline and atropine are both good muscarinic blockers but the former does not cross the blood-brain barrier because it has a quaternary nitrogen. This is an example of selectivity due to A. Differential topical application B. Distribution by selective carriers C. Differential blood flow D. Differential ionization E. Differential concentration by excretion. 2. Which of the following statements is FALSE ? A. Cooperativity of acetylcholine binding at the nicotinic acetylcholine receptor means that the binding of one acetylcholine molecule affects the affinity of the second acetylcholine molecule to bind. B. Ionotropic receptors can adopt one of three major conformational states: closed, open and desensitized. C. Cys-loop receptors, such as the ionotropic GABA and nicotinic receptors, are composed of four subunits. D. Glutamate receptor subunits have a re-entrant loop in transmembrane domain 2. E. Ionotropic GABA receptors can be made up of a wide variety of different subunits, resulting in receptors with differing pharmacological properties. 3. Inositol triphosphate (IP3) does which of the following A. Activates protein kinase C. B. Activates adenylyl cyclase. C. Inhibits adenylyl cyclase. D. Releases calcium from the endoplasmic reticulum into the cytoplasm. E. Activates phospholipase C. 4. If in a population 16% of the people exhibit a recessive disorder, what is the prevalence of the recessive gene in the population and what proportion of people are carriers but not afflicted? A. Gene prevalence 40%, percent population who are carriers 24%. B. Gene prevalence 40%, percent population who are carriers 48%. C. Gene prevalence 48%, percent population who are carriers 40%. D. Gene prevalence 36%, percent population who are carriers 24%. E. Gene prevalence 24%, percent population who are carriers 36%. 5. You are a physician treating an twelve year-old child who weighs 40 kg. If the adult dose of the drug you wish to prescribe is 10 mg/day how much drug should you give this child? A. 5 mg/day according to Young’s rule and 7 mg/day according to the body surface area calculation B. 7 mg/day according to Young’s rule and 5 mg/day according to the body surface area calculation. C. 10 mg/day according to Young’s rule and 7 mg/day according to the body surface area calculation D. 7 mg/day according to Young’s rule and 10 mg/day according to the body surface area calculation. E. 5 mg/day according to Young’s rule and 5 mg/day according to the body surface area calculation.
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6. Which of the following competes with penicillin for tubular secretion in the kidney?
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2007 test2 - Principles of Drug Action (BIO 365D) Test #2...

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