Lecture-06 Pharmacokinetics I

Lecture-06 Pharmacokinetics I - A review of fate of drugs...

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Unformatted text preview: A review of fate of drugs in the body . Pharmacokinetics The quantitative description of the rates of the various steps of drug disposition, including: 1. absorption of drugs 2. distribution to organs and tissues 3. elimination by biotransformation and excretion Why is this important? 1. Allows pharmacologists to characterize in detail the fates of drugs in the body and to identify factors that determine these fates. 2. Allows physicians to calculate dosing regimens (route, dose, frequency of drug administration). Relations among dose, plasma drug concentration and drug effect Dosage Concentration in plasma water Concentration at site of action Intensity of effect The duration of drug effects is generally related to the duration of its presence at the site of action. Pharmacodynamic studies investigate the intensities and time courses of the responses to drugs. Pharmacokinetic studies investigate the time course of drug concentrations in blood plasma and other tissues. Question: What makes pharmacodynamic studies potentially more difficult? Complications in relating drug plasma concentration & effect 1. Irreversibly acting drugs 2. Tolerance 3. Combinations of drugs with synergistic or antagonistic actions 4. Active metabolites Pharmacokinetics concerns itself with models of the fates of drugs in the body. These models require verification by experimental observation.verification by experimental observation....
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Lecture-06 Pharmacokinetics I - A review of fate of drugs...

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