Unit 5 pt 1 - Welcome to Section II II Cohort Studies Cohort Studies Part 1 Dr Borenstein Borenstein Amy R Borenstein Ph.D M.P.H Professor of

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Cohort Studies Part 1 Cohort Studies – Part 1 Dr Borenstein Dr. Borenstein NO AUDIO ON THIS SLIDE. CLICK NEXT TO CONTINUE >> Welcome to Section II ± Amy R. Borenstein, Ph.D., M.P.H. Professor of Epidemiology Room 2109 Friday 2 4pm 974 6670 ² Room 2109 Friday 2-4pm 974-6670 [email protected] ² Ph.D. from University of Washington, Seattle (1988) ² M.P.H. from University of Michigan, Ann Arbor (1980) ² Professional history: 1 year at EPA/Washington D.C., 1 year at Versar, Inc post-Master’s ² Switched from env. Epi to chronic disease; PhD at UW; worked 9 years at Battelle Memorial Institute; left UW; worked 9 years at Battelle Memorial Institute; left 1996 for USF ± Research Interests: Welcome to Section II ² 24 years in neuroepidemiology ² Focus on Alzheimer’s disease, vascular dementia, mild cognitive impairment ± Among first case-control studies in literature (dissertation) ± Case-control study of the potential role of aluminum in AD ± Cohort study of 1,985 Japanese-Americans (1991-2002), Kame Project, part of the Ni-Hon-Sea cross-national study of dementia and its subtypes among individuals of Japanese descent ± Cross sectional studies of African Americans (Hillsborough Elder African Cross-sectional studies of African Americans (Hillsborough Elder African American Life Study) and (prospective) Caucasians (Charlotte County Healthy Aging Study) ² Hurricane Charley Study ± Currently working on collaborations to set up a large cohort study of about 10 000 it d lli id t i Sh h i Chi t t d i k d 10,000 community-dwelling residents in Shanghai, China to study risk and preventive factors for brain atrophy, mild cognitive impairment and dementia ± Interests in gene-environment interactions, early detection of dementing illnesses and finding at-risk subjects in asymptomatic stages; ethnic differences in etiologic associations for dementia ± Multiple sclerosis ± Inflammatory Bowel Diseases (IBD) Study designs ± Observational ² Descriptive: ± Experimental ² Clinical trials ± Case report ± Case series ± Cross-sectional/ ² Intervention trials ² Prevention trials Correlational/ecologic ² Analytic: ± Prospective cohort ± Retrospective (or historical) cohor cohort ± Case-control ± Nested case-control Measures of association ± Analytic design ² “a study designed to examine associations, a study designed to examine associations, commonly putative or hypothesized causal relationships” Last JM, ed. A Dictionary of Epidemiology, 3rd edition. NY, Oxford University Press, IEA, Inc, 1995 ± Does Exposure (E) cause disease outcome (D)? P(y) = x P(D) = E Associations ± The extent to which things tend to occur together (non-directional) ² OR ± The statistical dependence between two variables ± In epidemiology, we would like to x y establish causal associations (uni- directional) x y
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Associations, con’d ± Prevalence ratio or odds ratio can tell us what the Prevalence ratio or odds ratio can tell us what the association is between E and D but can not necessarily tell us which came first (E Æ D or D Æ E, “chicken-or-egg”) ²
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This note was uploaded on 07/15/2011 for the course PHC 6000 taught by Professor Staff during the Summer '08 term at University of South Florida - Tampa.

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Unit 5 pt 1 - Welcome to Section II II Cohort Studies Cohort Studies Part 1 Dr Borenstein Borenstein Amy R Borenstein Ph.D M.P.H Professor of

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