unit 11 2

unit 11 2 - Overview Epidemiologic approaches can be...

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Unit 11 – Part 2 Natural History of Disease Natural History of Disease Levels of Disease Prevention Dr. A. Sanchez-Anguiano Overview ± Epidemiologic approaches can be applied to all types of disease, injury, and health conditions. ± Natural History of disease (N.H.) is a concept developed to explain the chain of infection, but it is also relevant to noninfectious diseases. Natural History of Disease Refers to the cours of the diseas from Refers to the course of the disease from its beginning to its final critical end points , in the absence of intervention. Natural History of Disease (cont.) ± The process begins with exposure to or accumulation of factors capable of causing disease. ± Without medical intervention the process ends with recoverydisability or death with recovery , disability . ± Several stages in the N.H. of diseases: Stage of susceptibility ± Stage of (prepathogenesis) ± Stage of subclinical disease (pathogenesis) ± Stage of clinical disease (pathogenesis Stage of (pathogenesis) ± Stage of recovery, disability death (postpathogenesis) Natural History of Disease (scheme) Pathologic change Usual time of diagnosis Exposure changes Onset of symptoms Stage o Stage of Stage o Stage of recovery Stage of susceptibility subclinical disease Stage of clinical disease Stage of recovery, disability or death Natural History of Disease (cont.) ± Most diseases have a characteristic N.H. ± For many diseases the N.H. is poorly For many diseases the N.H. is poorly understood. ± The time frame and specific manifestations may vary form individual to individual. ± With a particular individual the usual course may be halted at any point in the progression: ± preventive and therapeutic measures ± host factors ± other influences
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Natural History of Disease (cont.) ± The natural history starts with the exposure or
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unit 11 2 - Overview Epidemiologic approaches can be...

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