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Unformatted text preview: 1 Curb JD, Abbott RD et al. High Density Lipoprotein cholesterol and risk of stroke in elderly men: the Honolulu Heart Program. AJE 2004;160:150-7 H o : HDL cholesterol is not related to risk of stroke in older persons (men) without prevalent disease (clinical cardiovascular disease or cancer). H A : HDL cholesterol will be (inversely) related to risk of stroke Population: 1965 8 HHP 8 006 f J t li i O h HI f V t 1965-8: HHP 8,006 men of Japanese ancestry living on Oahu, HI from Veterans enrollment rolls followed for CHD and stroke Internal or external comparison group? Internal Age at study enrollment: 45-68 How were outcomes ascertained? Repeated examinations, follow-up of all hospital discharges, death certificates, autopsy records for morbidity/mortality due to CHD, cancer, stroke Why is Oahu a good place to do a study like this? Geographically delimited, limited migration, easy to reach all participants. Informed consent in every paper Curb et al, 2004, cond 2 Examination of 3,741 participants 1991-3 (80% of surviving cohort members) Methods Follow-up through Dec 1998 Exclude 1,192 men with prevalent disease Exclude 105 men with missing data on HDL 2,444 available for analysis Mean age at beginning of follow-up: 78 years Curb et al, 2004, cond 3 Definition of outcome All diagnoses reviewed and confirmed by study neurologist and HHP review committee Probable Possible Def of thromboembolic vs. hemorrhagic Curb et al, 2004, cond 4 Definition of exposure Standardized measurements Blood donation protocol Other risk factors: age, hypertension, diabetes,...
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- Spring '08