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Unformatted text preview: 1 Effect of a multivitamin and mineral supplement on infection and quality of life. A randomized, double-blind, placebo-controlled trial Barringer TA, Kirk JK, Santaniello AC, Foley KL, Michielutte R. Effect of a multivitamin and mineral supplement on infection and quality of life. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2003;138(5):365-71 Critique of an article. Dr. Sanchez-Anguiano Epidemiology & Biostatistics COPH/USF Background Use of multivitamin and mineral supplements is common among U S adults yet few wel U.S. adults, yet few well- designed trials have assessed the reputed benefits. Article Summary A randomized controlled trial was conducted on 130 community- dwelling adults aged 45 years or older and presence of type 2 diabetes mellitus. Information was collected on baseline measurements included Information was collected on baseline measurements included sociodemographic characteristics, clinical data, nutritional status, level of stress, health behaviors, and quality of life. Follow-up information on nutritional status was assessed with a 3-day food diary that participants kept at baseline and at 6 months. It was observed that a multivitamin and mineral supplement reduced the incidence of participant-reported infection and related absenteeism in a sample of participants with type 2 diabetes mellitus and a high prevalence of sub clinical micronutrient deficiency. Major Objective To assess the effect of a standard multivitamin and mineral multivitamin and mineral supplement on the development of infection and on quality of life. Hypothesis Multivitamin and supplement use is associated with a decreased incidence of infection and higher scores on the physical and mental health subscales of the Medical Outcomes Study 12- item short form....
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