3.%20%20Motor_ALS

3.%20%20Motor_ALS - ALS Anterior Lateral SClerosis Dr Brett...

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11/14/2009 1 ALS – Anterior Lateral SClerosis Dr Brett Lil ie 2009. Dr Brett Lil ie 2009. Neuromuscular Diseases CNS | UMN }ALS + SMA b LMN } / Peripheral N.Syst. } Guillian-Barre Syndrome b / Motor endplate } Myaesthenia Gravis b Mm (End organ) } Muscular Dystrophy, eg. Duchenne Muscle Dr Brett Lil ie 2009. Neuromuscular Diseases ALS occurs = muscular dystrophy 3 x more common than Myaesthenia Gravis Dr Brett Lil ie 2009. Neuromuscular Diseases Adult Motor Neuron Disease (or Amyotrophic Lateral Sclerosis-ALS) Progressive Muscular Atrophy Primary Lateral Sclerosis Amyotrophic Lateral Sclerosis } classified to Progressive Bulbar Palsy type of initial Pseudobulbar Palsy clinical features Dr Brett Lil ie 2009. Adult Motor Neuron Disease ALS (Lou Gehrig’s Disease) Relentless degenerative terminal disease that affects both UMN + LMN 1. Massive loss of Ant. Horn cells = amyotrophy of s.cord + motor C.N. of b. stem 2. Demtelination of corticosp tr. + corticobulbar tr Caused by degeneration in = lateral motor cortex sclerosis Results in upper motor neuron symptoms Dr Brett Lil ie 2009.
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11/14/2009 2 Adult Motor Neuron Disease Clinically Most common form of motor system disease. Depends primarily on identifying a collection of motor system changes According to World Federation of Neurology: Must have UMN + LMN signs in 3 spinal regions or 2 spinal regions + bulbar signs Excluded if a sensory or ANS dysfunction, CN3 or sign. mvt disorder. Dr Brett Lil ie 2009. Adult Motor Neuron Disease Clinically Progression of signs and symptoms is essential for diagnosis. Charcot first described ALS. Usually sporadic
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This note was uploaded on 07/15/2011 for the course ECON 2023 taught by Professor Johnson during the Summer '11 term at FAU.

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3.%20%20Motor_ALS - ALS Anterior Lateral SClerosis Dr Brett...

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