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Thin Layer Chromatography prelab

Thin Layer Chromatography prelab - Thin Layer...

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Thin Layer Chromatography (TLC) Analysis of Analgesics Prelab I. Introduction In organic chemistry, a desired compound (or a few desired compounds) is often mixed in small amounts with many other compounds in a complex mixture, making ordinary separation by extraction difficult in order to identify the compound(s). For these cases, thin layer chromatography (TLC) is an useful tool. As with extraction, TLC uses the differences between different compounds’ physical properties to separate them. However, instead of using the difference in boiling points (difference in how compounds move from the liquid to the gaseous phase), TLC uses the differences between distinct compounds’ ability to shift from a mobile phase versus a stationary phase to separate them. In a nutshell, the more affinity a substance has for the stationary phase, the slower it moves through a system, resulting in different substances in a mixture separating out from each other. In general, TLC is a quick and cheap method of separating components of a mixture, requiring only tiny amounts of the sample. In this lab, TLC was used to separate the components of the headache medicine Excedrin, as well as those of a
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