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keyexam - BCH 4053 May 1, 2003 FINAL EXAM NAME_KEY_ There...

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BCH 4053 May 1, 2003 FINAL EXAM NAME_____ KEY __________ There are 9 pages and 9 questions on the exam. Only five are to be answered, each worth 20 points. Answer two from questions 1, 2, 3, and 4 Answer three from questions 5, 6, 7, 8, and 9. (Only five questions total will be graded. If you answer more than the required number from either group, please indicate which ones are to be graded.) 1. Following is an alphabetical list of the glycolytic and TCA cycle enzymes plus a few other enzymes we have discussed. Choose enzymes from this list that are described by the statements below, and place the number or numbers of the enzyme in the blank to the left of the statement. In most cases, more than one enzyme will apply. Given in parenthesis after the statement is the target number of enzymes for you to identify. Page Points 1 ____ 2 ____ 3 ____ 4 ____ 5 ____ 6 ____ 7 ____ 8 ____ 9 ____ Total __ 100 _ (1) aconitase (2) aldolase (3) citrate synthase (4) enolase (5) fumarase (6) glucose-6-phosphate isomerase (phosphoglucoisomerase) (7) glyceraldehyde-3-phosphate dehydrogenase (8) hexokinase (9) isocitrate dehydrogenase (10) a-ketoglutarate dehydrogenase complex (11) malate dehydrogenase (12) malic enzyme (13) phosphoenolpyruvate carboxykinase (14) phosphofructokinase (15) phosphoglycerate mutase (16) phosphoglycerate kinase (17) pyruvate carboxylase (18) pyruvate dehydrogenase complex (19) pyruvate kinase (20) succinate dehydrogenase (21) succinyl-CoA synthetase (22) triose phosphate isomerase (a) ___ 9,10,12,13,17,18 _______ CO 2 is a substrate or a product. (six enzymes) (b) ___ 8,13,14,16,17,19 _______ ATP or GTP is a substrate or a product. (six enzymes) (c) ___ 3,10,18,21 ____________ Coenzyme A is a substrate or a product. (four enzymes) (d) ___ 7,9,10,11,18 ___________ NADH is a substrate or a product. (five enzymes) (e) ___ 10,18 ________________ Thiamine pyrophosphate is a prosthetic group. (two enzymes) (f) ___ 12,13,17 ______________ Possible anaplerotic reactions. (three enzymes) (g) ___ 7,9,10,11,12,18,20 ______ An oxidoreductase (six enzymes) (h) __ 3,8,9,10,14,17,18,19 ____ Operates removed from equilibrium (eight enzymes) minus 0.5 for each missing enzyme, minus 0.2 for an enzyme that doesn't belong up to maximum minus2.5 for each blank.
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BCH 4053 –Final Exam Page 2 Name______ KEY ______________ 2. Below are the partial structures of seven coenzymes you have studied. (a) Below each structure, draw an alternative form of the coenzyme to which it is converted during the course of a reaction. N S H N NH 2 O N N N NH O O H 3 C H 3 C A. B. C. N S N NH 2 O N H N N H NH O O H 3 C H 3 C H 3 C OH H H H N S H C O HO or (or COOH) (or COOH) S S HSCH 2 CH 2 HN NH S O O O O H 3 C O H 3 C CH 3 D. E. F. G. S HS SCH 2 CH 2 N NH S O O H 3 C O H 3 C CH 3 C O HO C O H 3 C HS HS C H 3 C O or (b) Complete the following table by giving the name of the coenzyme, identifying it as a cosubstrate or prosthetic group , and give the name of an enzyme that it reacts with. Structure Coenzyme Cosubstrate or Prosthetic Group? Enzyme (only one needed) A thiamine pyrophosphate Prosthetic group pyruvate dehydrogenase (DH) or alpha-ketoglutarate DH B NAD Cosubstrate glyceraldehyde-3-P DH, lactate DH, isocitrate DH, alpha-ketoglutarate DH malate DH, pyruvate DH, Complex I C FAD or FMN Prosthetic group succinate DH (aka Complex II), Complex I glycerol-3-P DH D lipoic acid Prosthetic group pyruvate DH, alpha-ketoglutarate DH E coenzyme A
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keyexam - BCH 4053 May 1, 2003 FINAL EXAM NAME_KEY_ There...

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