CMV - 2010 March 10th Cytomegalovirus Dr. Bredis...

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2010 March 10 th Cytomegalovirus Dr. Bredis Cytomegalovirus (CMV) Rough gradients of intensity of exchanging body excretions are the main reasons or infection spreading. - Infection is ubiquitous but nearly always inapparent. - Seropositivity rates o Ottawa 45% o Toronto 62% o Montreal 74% o Texas 79% o Burkina Faso 99.5% Acquisition of CMV A. Perinatal o 30-50% of infants infected during 1 st year of life o Probably representing vertical transmission (intrauterine and neonatal) o CMV present in maternal blood and breast milk B. Reproductive age o An additional 20-50% infected during the 2 nd and 3 rd decades of life o CMV is present in saliva and genital secretions Presence of virus Asymptomatic seropositive individuals commonly have infectious virus in many body fluids. - Urine, saliva, white blood cells, semen and vaginal secretions, breast milk and cerebrospinal fluid, and etc - CVM is present in many tissues despite presence of serum antibodies. Symptomatic CMV disease CMV virus rarely causes congenital disease, and it is often present in immunocompromised patients. It can be due to infection or reactivation during post-transplant immunosuppression. Their syndromes vary. - fever, hepatitis, pneumonia in transplant patients - Retinitis, pneumonia, esophagitis, and disseminated infections are common in AIDS patients (Eye infections).
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2010 March 10 th Cytomegalovirus Dr. Bredis Normal retina AIDS patient’s retina Hemorrhage is going in this retina.
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2010 March 10 th Cytomegalovirus Dr. Bredis
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2010 March 10 th Cytomegalovirus Dr. Bredis EBV (Ebstein Barr Virus) In North America, 90-95% of the poluation is seropositive by age 30. 50% of the population is seropositive by age 5. Remainder of EBV seroconverts during 2 nd and 3 rd decades of life. EBV is an oropharyugeal shedding of virus: - seropositive healthy adults: 10-25% - Recent transplant recipients: 50-75% - Acute infectious mononucleosis: 50-100% - Acute leukemia?AIDS: 85-100% This virus can spread simply by sneezing and coughing, therefore isolating patients is meaningless. Infectious mononucleosis by EBV Infectious mononucleosis is a syndrome and not a disease. This group of symptoms can be also seen from infections from other viruses such as HIV. - Symptoms o Fever, sore throat, and lymphadenopathy - Signs o Splenomegaly, hepatomegaly, palatal enanthem, jaundice, and rash - Not all infectious mononucleosis is caused by EBV. Lab Tests
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This note was uploaded on 07/20/2011 for the course BIO 431 taught by Professor Zieng during the Winter '10 term at McGill.

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CMV - 2010 March 10th Cytomegalovirus Dr. Bredis...

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