EAS procedure - Exp. 1 Electrophilic Aromatic Substitution...

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Exp. 1 Electrophilic Aromatic Substitution Preparation and Separation of o- and p-Nitroaniline Chapter 27, p 243 of Bell, Clark and Taber Review the chapter on Electrophilic Aromatic Substitution in Bruice. Pay special attention to the mechanism for nitration, and the directive and activating effects of substituents. Work in the fume hood and make sure your goggles are on for the entire lab period! Please take care when handling concentrated acids. Do not take more reagents than you will use. N CH 3 H O acetanilide HNO 3 H 2 SO 4 N CH 3 H O NH 3 + HSO 4 - NH 2 NH 4 OH H 2 O makes H 3 O + NO 2 NO 2 NO 2 Weigh 2.7 g of acetanilide and place it in a 125-mL Erlenmeyer flask. Measure 9 mL of concentrated sulfuric acid in a graduated cylinder and pour half of the acid into the flask. Stir and swirl the mixture until almost all of the acetanilide has dissolved. Be patient. Do not add more than 5 mL of acid at this time. Small amounts of remaining solid will dissolve later. Cool the reaction in an ice water bath. Measure out 1.5 mL of concentrated nitric acid and add it to
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This note was uploaded on 07/21/2011 for the course CHM 2230 taught by Professor Kadango during the Spring '10 term at Wayne State University.

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EAS procedure - Exp. 1 Electrophilic Aromatic Substitution...

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