Lecture-1SS - Introduction & General Applications...

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Unformatted text preview: Introduction & General Applications of BioMaterials – Lecture Slide Set 1 Lecture Dr. Anthony Brennan University of Florida Tel: 352.392.6281 Email: abrennan@mse.ufl.edu EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 EMA 1 Guidelines • Approach – Lecture – Demonstrations • Interactive – Designed for questions • • Verbal Written • Content – Variable based upon class – Adjustable based upon requests EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 EMA 2 Lecture 1 - Introduction, Fundamentals, Nomenclature, Lecture applications of biomaterials applications • Learning Objectives: – Course overview • Text: Text: ..\..\ema6580\EMA6580-Sci-of-Biomaterials-ABET-Syllabus-Spring-2011.pdf ..\..\ema6580\EMA6580-Sci-of-Biomaterials-ABET-Syllabus-Spring-2011.pdf • Grading • Schedule: Schedule: ..\..\ema6580\EMA6580-Sci-of-Biomaterials-Lecture-Schedule-Spring-2011.pdf ..\..\ema6580\EMA6580-Sci-of-Biomaterials-Lecture-Schedule-Spring-2011.pdf – Research Proposal • NIH Guidelines: ..\..\ema6580\Research_Proposal_Guidelines.pdf NIH ..\..\ema6580\Research_Proposal_Guidelines.pdf – Biomaterials • • • Areas of Research - MSE Applications/Devices Issues – Time Dependent – Life Cycle EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 EMA 3 Material Properties • • • • • • Chemical Physical Electronic Magnetic Optical Bioactivity CERAMICS METALS PROPERTIES ELECTRONIC MATERIALS EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 EMA POLYMERS 4 Biomaterials Biomaterials • “A biomaterial is a nonviable material used in a biomaterial medical device, intended to interact with biological medical systems.” (Attributed to Williams 1987, cited in Biomaterials Science, ed Ratner, Hoffman, Schoen and Lemons, John Wiley & Sons, Inc., p2) Sons, • “Biocompatibililty is the ability of a material to Biocompatibililty perform with an appropriate host response in a specific application” (Attributed to Williams 1987, cited in specific Biomaterials Science, ed Ratner, Hoffman, Schoen and Lemons, John Wiley & Sons, Inc., p2) Sons, • Issues to consider: – – – Viability Temporal Placement EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 5 Biomaterials Research Biomaterials Materials Science and Engineering Materials University of Florida University Silylation Parkensons Research (Baney) Understanding Dental Fracture (Mecholsky) Quantum Dot Bioimaging Research (Holloway) Alzheimers/Fe Research (Batich) Improved Ocular Lens Implants (Goldberg) Spinal Cord Repair Scaffolds Spinal Bioactive Tissue Constructs Bioactive (Goldberg) (Goldberg) (Allen, Brennan, Hench) (Allen, Drug Encapsulation Chemotherapy (Goldberg) Post-operative Adhesion Reduction Drug Encapsulation Insulin (Singh) (Goldberg) Wound Healing with Bound Microbicide (Batich) Particles for Blood Detoxification (Gower) Hyperthermia of Liver Cancer (Batich) New Antibiotics: Silanols (Baney) (Baney) New Surfaces (Brennan) Surfaces Improved Kidney Dialysis Membranes (El Shall) Biomimetic Bone Formation Kidney Regeneration Stem Cell Scaffolds (Allen, Brennan, Gower) (Batich) Bone Fracture (Mecholsky) Ingestible Sensors (Hess) Engineered Vascular Constructs (Allen, Brennan) EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 EMA Created by Professor Kevin Jones, Chair, Materials Sci & Eng, University of Florida – November 2006 6 Applications of Biomaterials (Medical) Applications Application Types of Materials Replacement Joints, Plates, Srews Ti, Ti-Al-V, SS, UHDPE/UHMWPE, Allografts Bone replacement/regeneration Hydroxyapatite, Glass-Ceramics, DMC, CAP, Stem Cell Bone cements PMMA, BisGMA, TEGDMA Artificial tendon and liigament ePTFE, PET Dental Restoratives and Implant Methacrylates, Ti, Alumina, PFM, Ca(PO4)2 Skeletal System Cardiovascular System Vascular implants PET, ePTFE, autografts, allografts, SIS Heart Valves xenografts, SS, carbon/PET Catheters PDMSe, PUR, HDPE, PTFE, Polyamides Cardiovascular Tissue Stem Cells, autografts, allografts Artificial Heart (VADs) PUR, PC, PDMSe Skin replacement PDMSe-Collagen Composites, HEMA hydrogels Kidney, Bladder Cellulose, PAN, SIS Heart-Lung Machine PDMSe Dialysis PDMSe, Cellulose, PSF Organs Sensory Cochlear Implants EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 Pt 7 Medical Health Care in US Medical • Cardiovascular Diseases and Strokes – $475 Billion per year (2009) • American Heart Association – $508 Billion – including health care and lost productivity • CDC Report • Coronary Heart Disease – $120.6 Billion per year (2008) • The Silverbook Report • CVD Mortality – 958,775 lives per year (1/33 sec) • Florida’s Taxable Resources – $953.9 Billion (2007) • US Treasury Report • NIH Budget for NHLBI (2008) NIH (2008) • – $29.2 Billion – $9.8 Million (Grants ONLY) Source: American Heart Association Web page • Federal Transportation Funding – $67 Billion (2008) $67 (2008) Issues to Consider Issues • Ethics • Analyses – “Do no harm” • • • • • Function Life Cycle Toxicology Patient Compliance Education – – – – • • • Chemical Mechanical Electronic Biologic Manufacturing Clinical Regulatory EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 9 Importance of Chemistry Protein Tertiary Structure Conformational Structure Random Confirmation - Dilute Lamellar Configuration - Secondary Helical Configuration - Tertiary EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 EMA 10 Importance of Chemistry • Balance of Three Energies – Intermolecular – Intramolecular – Thermal (kT) • Structures – Linear – Branched EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 EMA 11 Characteristic Atomic Bonds EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 EMA 12 Summary • Biomaterials are designed to function in Biomaterials specific applications for limited time to enhance or replace tissues. enhance • Biomaterials design requires a team Biomaterials approach. approach. • Biomaterials require constant Biomaterials improvements as knowledge increases. improvements • Health Care Costs Growth outpace GD.P • Ethics are the key to successful Ethics development and implementation of biomaterials. biomaterials. EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 EMA 13 Additional References • “Biomaterials Science – An Biomaterials Introduction to Materials in Medicine,” Ed. B. D. Ratner, A. S. Hoffman, F. J. Schoen, and J. E. Lemons, Academic Press, 1996, ISBN: 0-12-582460-2 Press, • Web resources listed in lecture EMA 6580 Science of Biomaterials - University of Florida Copyright 2009 EMA 14 ...
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