Paper24-Varying-Polymer-Architecture-to-Deliver-Drugs-AAPS-Journal-9(2)-Article-26-Heath-et-al(2007)

Paper24-Varying-Polymer-Architecture-to-Deliver-Drugs-AAPS-Journal-9(2)-Article-26-Heath-et-al(2007)

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The AAPS Journal 2007; 9 (2) Article 26 (http://www.aapsj.org). E235 A BSTRACT Variable architecture polymers are of considerable interest for the delivery of therapeutic biopolymers, such as DNA and proteins, to their site of action. Polymers that can respond with a change in conformation to biologically relevant stimuli, such as temperature and pH, are being carefully designed to take advantage of the change in envi- ronmental conditions the polymer-drug conjugate encoun- ters upon progression from larger-scale systems in the body to subcellular compartments. Viruses respond to changes in the cellular environment to gain access to their desired region of cells, and much can be learned from the mecha- nisms they employ in this effort. However, despite the ef f - ciency of therapeutic biopolymers, undesirable immune and in F ammatory responses may result from their repeated administration, so synthetic polymers are an attractive alter- native. This mini-review examines a range of recently developed variable architecture polymers, mainly focusing on polymers responsive to temperature and pH, covering both synthetic copolymers and derivatives of naturally occurring polymers for advanced drug delivery applications. The polymers discussed in the article have some of the properties that are most important for polymer drug delivery vehicles to be effective, such as biodegrad- ability, speci f city, and biocompatibility. K EYWORDS: Smart polymers , drug delivery , biotherapeutics INTRODUCTION Delivering drugs to target sites in the body at the right time and in the right dose remains a formidable challenge. This is especially the case for biomacromolecular drugs such as DNA, RNA, short interfering RNA, and therapeutic pro- teins. Biomacromolecules such as those above injected directly into tissue drain rapidly into the lymphatic system. Furthermore, these complex biopolymers are readily deac- Corresponding Author: ±Cameron±Alexander,±±School±of± Pharmacy, Boots Science Building, University of Nottingham, University Park, Nottingham NG7 2RD, UK . Tel: +44 (0) 115 846 7678 ; Fax: +44 (0) 115 951 5102 ; ±E-mail:±±cameron.alexander@nottingham.ac.uk± Themed Issue: Nanotechnology and Drug Delivery Guest Editors - Craig K. Svensson and Alexander V. Kabanov ±Varying±Polymer±Architecture±to±Deliver±Drugs± ±Submitted:±±February±±28± ,±±2007±;±Accepted:±±May±±18± ,±±2007±;±Published:±June±22,±2007 ±Felicity±±Heath± 1 ±±Prinal±±Haria± 1 ±±and±Cameron±±Alexander± 1 1 School of Pharmacy, Boots Science Building, University of Nottingham, University Park, Nottingham NG7 2RD, UK tivated by enzymes such as DNases and proteases outside their normal biological environment and hence require a carrier vehicle or protective agent when administered as a drug. The delivery vehicles in turn must be able to transport the drug across biological barriers to the target site without causing an unwanted response. The human immune system, for example, has evolved to produce more than 10 8 ±anti- bodies and more than 10 12
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This note was uploaded on 07/25/2011 for the course EMA 6580 taught by Professor Staff during the Spring '08 term at University of Florida.

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Paper24-Varying-Polymer-Architecture-to-Deliver-Drugs-AAPS-Journal-9(2)-Article-26-Heath-et-al(2007)

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