Paper33-Novel-vascular-graft-peritoneal-cavity-Circ-Res-1173-Campbell-et-al-(1999)

Paper33-Novel-vascul - ISSN 1524-4571 Copyright © 1999 American Heart Association All rights reserved Print ISSN 0009-7330 Online TX 72514

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Unformatted text preview: ISSN: 1524-4571 Copyright © 1999 American Heart Association. All rights reserved. Print ISSN: 0009-7330. Online TX 72514 Circulation Research is published by the American Heart Association. 7272 Greenville Avenue, Dallas, 1999;85;1173-1178 Circ. Res. Julie H. Campbell, Johnny L. Efendy and Gordon R. Campbell Novel Vascular Graft Grown Within Recipient’s Own Peritoneal Cavity http://circres.ahajournals.org/cgi/content/full/85/12/1173 located on the World Wide Web at: The online version of this article, along with updated information and services, is http://www.lww.com/reprints Reprints: Information about reprints can be found online at [email protected] 410-528-8550. E-mail: Fax: Kluwer Health, 351 West Camden Street, Baltimore, MD 21202-2436. Phone: 410-528-4050. Permissions: Permissions & Rights Desk, Lippincott Williams & Wilkins, a division of Wolters http://circres.ahajournals.org/subscriptions/ Subscriptions: Information about subscribing to Circulation Research is online at at HEALTH SCIENCE LIBRARY on March 31, 2009 circres.ahajournals.org Downloaded from Novel Vascular Graft Grown Within Recipient’s Own Peritoneal Cavity Julie H. Campbell, Johnny L. Efendy, Gordon R. Campbell Abstract —A method by which to overcome the clinical symptoms of atherosclerosis is the insertion of a graft to bypass an artery blocked or impeded by plaque. However, there may be insufficient autologous mammary artery for multiple or repeat bypass, saphenous vein may have varicose degenerative alterations that can lead to aneurysm in high-pressure sites, and small-caliber synthetic grafts are prone to thrombus induction and occlusion. Therefore, the aim of the present study was to develop an artificial blood conduit of any required length and diameter from the cells of the host for autologous transplantation. Silastic tubing, of variable length and diameter, was inserted into the peritoneal cavity of rats or rabbits. By 2 weeks, it had become covered by several layers of myofibroblasts, collagen matrix, and a single layer of mesothelium. The Silastic tubing was removed from the harvested implants, and the tube of living tissue was everted such that it now resembled a blood vessel with an inner lining of nonthrombotic mesothelial cells (the “intima”), with a “media” of smooth muscle–like cells (myofibroblasts), collagen, and elastin, and with an outer collagenous “adventitia.” The tube of tissue (10 to 20 mm long) was successfully grafted by end-to-end anastomoses into the severed carotid artery or abdominal aorta of the same animal in which they were grown. The transplant remained patent for at least 4 months and developed structures resembling elastic lamellae. The myofibroblasts gained a higher volume fraction of myofilaments and became responsive to contractile agonists, similar to the vessel into which they had been grafted....
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Paper33-Novel-vascul - ISSN 1524-4571 Copyright © 1999 American Heart Association All rights reserved Print ISSN 0009-7330 Online TX 72514

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