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Unformatted text preview: 21)
(40) mRNA increased, while that of collagen I mRNA was
unchanged (Fig. 10). Discussion
In this study, we analyzed periprosthetic tissues from
patients with aseptic loosening and demonstrated the
presence of macrophage/histiocytes, foreign body giant
cells, and polyethylene particles in various grades.
These ﬁndings were consistent with previous histological studies on osteolysis in joint replacement5,6,18 484 S. Ito et al.: Granulation tissue in osteolysis Fig. 5. Relationship of the histological
grade of particles or giant cells in the
granulation tissue around the socket between prostheses with and without cement. Bars represent the mean SEM b a c and experimental animal models.13,16 Unexpectedly,
polyethylene particles were not always present in our
samples, similar to the results shown by Kim et al.14 that
the percentage of specimens with polyethylene particles
graded as moderate or severe was 52%–63%. This may
be explained as follows: osteolysis...
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This note was uploaded on 07/25/2011 for the course EMA 6580 taught by Professor Staff during the Spring '08 term at University of Florida.
- Spring '08