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However, the distribution was heterogeneous, and no particles were found microscopically in about 30%–40% of
periprosthetic tissues, and in 60% of capsules. The amount of
particles correlated with giant cells, but not with histiocytes.
The conditioned medium of the granulation tissue culture
stimulated osteoblasts to produce interleukin-6 in both protein and mRNA, and this was in part inhibited by anti-tumor
necrosis factor-α or the interleukin-1 antibody, suggesting
that interleukin-6 production is mediated by several
cytokines. These ﬁndings suggest that interleukin-6, which is
produced not only by macrophages but also by osteoblasts, is
a contributing factor to aseptic loosening. particles in the granulomatous tissue around the prosthesis, suggesting that this is the principal cause of
It has been reported that particulate debris stimulates
macrophages to release many chemical mediators such
as cytokines, which induce bone resorption.1,8 However,
the detailed mechanisms of osteolysis rema...
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This note was uploaded on 07/25/2011 for the course EMA 6580 taught by Professor Staff during the Spring '08 term at University of Florida.
- Spring '08