Paper35-Histological-biological-effects-granulation-tissue-loosened hip-development-osteolysis-J-Ort

However the distribution was heterogeneous and no

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Unformatted text preview: ght. However, the distribution was heterogeneous, and no particles were found microscopically in about 30%–40% of periprosthetic tissues, and in 60% of capsules. The amount of particles correlated with giant cells, but not with histiocytes. The conditioned medium of the granulation tissue culture stimulated osteoblasts to produce interleukin-6 in both protein and mRNA, and this was in part inhibited by anti-tumor necrosis factor-α or the interleukin-1 antibody, suggesting that interleukin-6 production is mediated by several cytokines. These findings suggest that interleukin-6, which is produced not only by macrophages but also by osteoblasts, is a contributing factor to aseptic loosening. particles in the granulomatous tissue around the prosthesis, suggesting that this is the principal cause of osteolysis.5,6,18 It has been reported that particulate debris stimulates macrophages to release many chemical mediators such as cytokines, which induce bone resorption.1,8 However, the detailed mechanisms of osteolysis rema...
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This note was uploaded on 07/25/2011 for the course EMA 6580 taught by Professor Staff during the Spring '08 term at University of Florida.

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