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osteoblast culture medium, alone or in combination with
10 µg/ml antibody for IL-1 (IL-1 Ab) or for TNF-α (TNF
Ab), 10 4 M indomethacin (Ind), or 10 6 M dexamethasone
(DEX). IL-6 was not detected in the medium before the culture. After 24 h of culture, the IL-6 levels were measured.
Values are the mean
SEM. Asterisks denote a signiﬁcant
difference compared with treatment by conditioned medium
alone (* P 0.05, ** P 0.01) We compared the histological grading with the clinical ﬁndings and found more particles in tissue around a
noncemented socket. Although the histological differences between cemented and noncemented implants
are controversial,7 Jones et al.12 showed that immunohistochemical staining for cytokines is similar in both
groups. Several cytokines, such as IL-6, TNF-α, and IL1 , have been identiﬁed immunohistologically or by in
situ hybridization.7,11,12,25 These cytokines are considered
to have been produced by particle-stimulated macrophages and to have played a role in bone resorption. In
agreement with this, w...
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This note was uploaded on 07/25/2011 for the course EMA 6580 taught by Professor Staff during the Spring '08 term at University of Florida.
- Spring '08