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Unformatted text preview: in unknown.
Not only particulate debris but also mechanical stress
contributes to loosening of the prosthesis.17 These ﬁndings suggest heterogeneity in the histology of granulation tissue around the prosthesis, but an insufﬁcient
number of samples have been observed to date. Therefore, we investigated 82 samples from patients with
aseptic loosened hip prostheses, and compared the histological ﬁndings of capsules and granulation tissue
around the prostheses. To investigate their biological
effects on osteolysis, we cultured tissue from a patient
with massive osteolysis. Compared with those on
macrophages or osteoclasts,1,10,15,19,20,29 few studies have
focused on the behavior of osteoblasts in osteolysis.4,12
Therefore, in this study, we also examined the effects
of conditioned medium from periprosthetic tissue on
osteoblasts in vitro. Key words Aseptic loosening · Osteolysis · Granulation tissue Materials and methods
Although total joint replacement is beneﬁcial for
patients with joint disease, aseptic loosening of the prosthesis is...
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This note was uploaded on 07/25/2011 for the course EMA 6580 taught by Professor Staff during the Spring '08 term at University of Florida.
- Spring '08