Paper35-Histological-biological-effects-granulation-tissue-loosened hip-development-osteolysis-J-Ort

Not only particulate debris but also mechanical

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Unformatted text preview: in unknown. Not only particulate debris but also mechanical stress contributes to loosening of the prosthesis.17 These findings suggest heterogeneity in the histology of granulation tissue around the prosthesis, but an insufficient number of samples have been observed to date. Therefore, we investigated 82 samples from patients with aseptic loosened hip prostheses, and compared the histological findings of capsules and granulation tissue around the prostheses. To investigate their biological effects on osteolysis, we cultured tissue from a patient with massive osteolysis. Compared with those on macrophages or osteoclasts,1,10,15,19,20,29 few studies have focused on the behavior of osteoblasts in osteolysis.4,12 Therefore, in this study, we also examined the effects of conditioned medium from periprosthetic tissue on osteoblasts in vitro. Key words Aseptic loosening · Osteolysis · Granulation tissue Materials and methods Introduction Although total joint replacement is beneficial for patients with joint disease, aseptic loosening of the prosthesis is...
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This note was uploaded on 07/25/2011 for the course EMA 6580 taught by Professor Staff during the Spring '08 term at University of Florida.

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