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Paper35-Histological-biological-effects-granulation-tissue-loosened hip-development-osteolysis-J-Ort

Paper35 histological biological effects granulation

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Unformatted text preview: J Orthop Sci (2004) 9:478–487 DOI 10.1007/s00776-004-0808-1 Histological analysis and biological effects of granulation tissue around loosened hip prostheses in the development of osteolysis Shigeru Ito , Tomoko Matsumoto , Hiroshi Enomoto, and Hiroyuki Shindo Department of Orthopedic Surgery, Nagasaki University, School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan Abstract Although aseptic loosening of the prosthesis is a long-term complication after total joint replacement, the detailed mechanism of osteolysis remains unknown. We examined 82 samples from 40 patients with aseptic loosened hip prostheses histologically, and compared the distribution of particles, macrophages/histiocytes, and foreign body giant cells in the retrieved tissue from capsules and around prostheses. Furthermore, to investigate the mechanism of osteolysis, we cultured tissue from a patient with massive osteolysis and examined the effects of the conditioned medium on osteoblasts in vitro. Numerous multinucleated giant cells and histiocytes were present, and polyethylene particles ranging from medium to large were identified in the polarized li...
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