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AIDS- BICD 136 - AIDS Pandemic I AIDS acquired immune...

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AIDS Pandemic June 25, 2011 I. AIDS- acquired immune deficiency syndrome People with aids don’t all have the same constellation of systems, Collection of conditions List of AIDS defining illness, may not necessarily have all the same ones Depresses your immune system Example of immune deficiency besides AIDS o Genetic defect (some severe, some not severe) o John Travolta’s “ Bubble Boy” about a child w/o an immune system o Chemo or radiation o Organ transplants- take drugs to inhibit immune system so body can take new organ o *young new healthy men w/o any of this = why it was a mystery II. People with AIDS die of cancers, infections that spread throughout -> both ultimately lead to organ failure underlying cause = collapse of immune system HIV - human immunodeficiency virus o ( lives in the immune system- specifically the T4 CELLS) o if you take out T4 cells, everything crashes -> why HIV is so devastating Every virus has a place it hones to (where it lives) HIV+ is someone infected w/ HIV HIV+ is not proportional to AIDS ( don’t necessarily have AIDS) o 10-12 years before HIV people get AIDS, in the ABSENCE of treatment o w/ treatment, may possibly extend it indefinitely o when babies are infected at birth, they only last two years o immune system which is related to genetic makeup, nutrition status, etc. will all influence the duration o HIV+ means that they are testing the antibodies to detect o AIDS is defined as being HIV+ AND one of two things: either T4 cells destroyed to a certain level(healthy starts at 1000- unhealthy goes to less than 200 T4 cells/ microliter blood) OR have an AIDS defining illness o 1% of caucasian male population- mutation where they can’t get it o some other percentage won’t show symptoms o elite controllers- whether they can control the virus forever o when a person is HIV+-> considered to be infectious for the rest of their life
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o where is the target cell? T4 is congregating in lymphoid tissue ( in the gut, on the outside of the intestines) o also find cells in bodily fluids o transfer AIDS infected bodily fluid gets into the body of another person blood, semen, breast milk, saliva, cervical fluid-> most likely to transfer HIV some in amniotic fluid and bone marrow as well HIV won’t infect you through skin unless there is a cut/opening It has to go through a mucous membrane (easily penetrated by the virus)-> eyes, mouth, anus tract, genital tract, and blood o Mode: 1. Sex (mainly via men)-> sex is the most efficient way to transmit guys are more likely to infect than women ^ look at the numbers 2. IV drug use sharing of the needles and syringes mother to child (vertical transmission) 3 ways to transmit: o 1. In utero (during gestation, HIV can move across the placenta.. usually late) o 2. At birth ( the babies eyes and mouth are exposed to the blood and vaginal fluid of the mother o 3. Breastfeeding Saliva is not infectious- no case of it ever being transmitted
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AIDS- BICD 136 - AIDS Pandemic I AIDS acquired immune...

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