Synaptic Plasticity

Synaptic Plasticity - Long-term plasticity - mechanism to...

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Long-term plasticity - mechanism to change connections   Aplesia - pruning of motor neurons that elicit siphon response   Stimulate Activity - strengthen connection between synapses   Long-Term Potentiation (LTP)      Drive group A presynaptic neurons and record postsynaptic response of group B 1. Tetnus (100Hz) 2. A large group of postsynaptic neurons to fire Aps 3. Synaptic strengthening Response on neuron B will be stronger after delivery of tetnus   LTP resembles memory  Happens in seconds Last for minutes or days Sensitive during consolidation   What is so special about NMDA receptors so that they are basically required in plasticity? Under basic conditions receptors are blocked by magnesium a. Magnesium binding Only allow influx of calcium and sodium if glutamate is bound and the postsynaptic  membrane is sufficiently depolarized to kick the magnesium out a. Depolarization = Coincidence Detectors   Hebb's Postulate : In order to get strengthening between two neurons you have to get  firing in close proximity to one another   Postsynapse of NMDA: Complement of NMDA and AMPA receptors o Both sensitive to glutamate When NMDA receptors are stimulated by tetnus =>  drive neurochemical cascade that 
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This note was uploaded on 04/05/2008 for the course BIOL 455 taught by Professor Sabrinaburmeister during the Spring '08 term at UNC.

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Synaptic Plasticity - Long-term plasticity - mechanism to...

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